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A Novel Therapy For Renal Care

Chronic Renal Failure (CRF)

Renochlor

An innovative, proprietary & patent pending product of THINQ Pharma CRO Pvt Ltd which reduces dialysis burden and enhances QoL (Quality of Life) in CRF (Chronic Renal Failure)

The composition of Renochlor Formulation

The active molecule Renochlor is Sodium Copper Chlorophyllin. During the synthesis of chlorophyllin, the magnesium atom at the centre of the ring is replaced with copper and the phytol tail is lost. Unlike natural chlorophyll, chlorophyllin is water-soluble. The formulation is not poly-herbal and contains sorbitol and glycerine as adjuvants for better drug delivery.

The composition of Renochlor Formulation

The active molecule Renochlor is Sodium Copper Chlorophyllin.During the synthesis of chlorophyllin, the magnesium atom at the centre of the ring is replaced with copper and the phytol tail is lost. Unlike natural chlorophyll, chlorophyllin is water-soluble. The formulation is not poly-herbal and contains sorbitol and glycerine as adjuvants for better drug delivery.

About Sodium Copper Chlorophyllin

Traditionally Sodium copper chlorophyllin is used as a food colour. It has 21 CFR declaration as safe for human consumption (19862 Federal Register / Vol. 55, No. 82 / Friday, May 21, 1990) and USFDA monograph (19862 Federal Register / Vol. 55, No. 82 / Friday, May 21, 1990 ). In Europe it is acceptable as a safe food additive, Ref no. E140 and is a GRAS Product (Generally recognised as safe)

Development history

It is hypothesized that Cu-chlorophyllin molecule shares the same functional structure that of haemoglobin molecule - the porphyrin ring. One end of Cu-chlorophyllin molecule is hydrophilic which can get attached to water like molecules and the other end is hydrophobic which can get attached to lipids. This unique structure allows the Cu-chlorophyllin molecule to dissolve and get into the bloodstream and reach all parts of the body
The porphyrin ring has more affinity towards heavy metals and nephrotoxic elements. The Cu ion in the porphyrin ring is dynamic and when it comes in contact with the heavy metals & toxins the Cu ion gets exchanged for the heavy metals, ions and toxins get attached on the ring thereby getting excreted out of the body.
The result is a decrease in the level of serum creatinine and serum urea which are considered as important markers of the kidney function.

Choose Renochlor for better management of CRF

  • There is currently no product in the market similar to Renochlor, though there are a few that are used as adjuvant therapy for CRF.
  • Products like Ketosteril and Nefrosteril used for CRF patients are associated with strict lifestyle changes for effectiveness.
  • Clinical Trails suggest Renochlor improves Quality of life in CRF patients significantly.

Clinical Trials

A single arm prospective study comprising of 34 patients, who were administered 3 doses (10 ml per dose) of the formulation for a period of 2 months with a follow-up of no medicine for one month thereafter, was conducted. For all the patients, standard care of the treatment was continued during the follow-up period. Inclusion criteria included CRF non-dialysis patients aged between 18 and 70 years with Serum Creatinine more than 1.8 mg/dL. Assessment of QoL was based on a WHO questionnaire which has been specifically designed for CRF patients.

The primary objective of the trial was to study the efficacy of Syrup Renochlor in reducing Serum Creatinine in CRF patients and the secondary objective was to see the efficacy of Syrup Renochlor in reducing blood urea, increasing haemoglobin and improving Quality of Life (QoL) in CRF patients.

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About THINQ

THINQ Pharma group of companies situated in Singapore and Mumbai having a worldwide presence was established in 1989. We are a vertically integrated pharmaceutical company with API’s and Formulation segments and a robust clinical research wing. THINQ Pharma has more than 25 years of experience in the international markets of USA, Singapore, South Africa and South East Asia.

With research of more than 4 years, THINQ has developed a plethora of natural products for enhancing and addressing health and wellness.